Essentials of Genomics and Bioinformatics

Introduction . . 1

Application Domains
1 Genome Projects of Model Organisms . . 5
2 The Human Genome Project . . 41
3 Genetic Discases . . 61
4 Pharmaceutical Bioinformatics and Drug Discovery . . 105
5 Agri-Food and Genomics . . 127

DNA Technologies
6 Genomic Mapping and Positional Cloning with Emphasis on Plant Science . . 145
7 Sequencing Technology . . 165
8 A DNA Microarray Fabrication Strategy for Research Laboratories . . 209

Potein Technologies
9 Two-Dimensional Gel Electrophoresis and Mass Spectrometry for Proteomic Studies: State-of-the-Art . . 223
10 Proteome Analysis by Capillary Electrophoresis . . 253
11 Using the Molecular Biology Data . . 263
12 Tools for DNA Technologies . . 285
13 Tools for Protein Technologies . . 309
14 Structure Information . . 329
15 Genomic Data Representation through Ethical, Legal and Social Issues Images - MAGPIE as an Example . . 345
16 Interaction Databases . . 365
17 Ethical Aspects of Genome Research and Banking . . 381
18 Genomics - Five Years from Now . . 397

Index . . 407